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2 edition of effects of sodium taurocholate and albumin on renal function in the rat. found in the catalog.

effects of sodium taurocholate and albumin on renal function in the rat.

Jane Anne Sharples

effects of sodium taurocholate and albumin on renal function in the rat.

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  • 17 Currently reading

Published by University of Manchester in Manchester .
Written in English


Edition Notes

Manchester thesis (Ph.D.), Faculty of Medicine.

ContributionsUniversity of Manchester. Faculty of Medicine.
The Physical Object
Pagination341p.
Number of Pages341
ID Numbers
Open LibraryOL16571077M

Effects of Chronic Exposure to Sodium Arsenate on Kidney of Rats Namdar Yousofvand *1, Mohammad Fahim 2 Received: Accepted: ABSTRACT Background: In the present study, histopathological effects of chronic exposure to sodium ar-. Colistin was found to be slowly metabolized in (rat >human) hepatocytes, apparently without involvement of CYP enzymes. The hepatic metabolism could explain a major part (%, IVIVE predicted CL/observed mean value from 3 studies) of its non-renal clearance of colistin.   Low blood pressure causes the kidneys to release renin, which in turn causes the production of angiostensin II. Angiotensin II increases the secretion of the hormone aldosterone by the adrenal cortex. Aldosterone causes increased reabsorption of of sodium. Water is reabsorbed with sodium, increasing blood pressure. Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the .


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effects of sodium taurocholate and albumin on renal function in the rat. by Jane Anne Sharples Download PDF EPUB FB2

In light of clinical and biological evidence that bile constituents exert preventive effects against colorectal cancer, we evaluated the influence of oral bilirubin and sodium taurocholate (NaTC) on intestinal tumor formation in APC Min/+ mice.

Mice received bilirubin and/or bovine serum albumin (BSA) and NaTC in the drinking water for 8 weeks, after which the number, size and Cited by: The effect of starvation on urinary output and biochemical indices of renal function was investigated in rats.

Starvation resulted in a marked fall in water intake. Urinary output paradoxically increased during the first day following starvation, but fell dramatically by: Conclusions.

Chronic high-salt diet decreased claudin-2 protein and increased renal TRPV5, calbindin-D 28k, and loading is known to reduce the proximal tubular reabsorption of both Na + and Ca 2+.The reduction in claudin-2 protein expression may be partly responsible for the reduced Ca 2+ reabsorption in this segment.

The concerted upregulation of more distal Ca. Sabordo L, Sallustio BC () Effects of gemfibrozil and clofibric acid on the uptake of taurocholate by isolated rat hepatocytes. Biochem Pharmacol – PubMed CrossRef Google Scholar Saeki T, Kuroda T, Matsumoto M, Kanamoto R, Iwami K () Effects of Cys mutation on taurocholic acid transport by mouse ileal and hepatic sodium Cited by: Sodium taurocholate increases hydraulic conductivity in rabbit cortical collecting tubule.

Abnormalities in renal tubular function occur commonly in the setting of hyperbilirubinemia. In the present studies, the possibility that the bile salt sodium taurocholate exerts a direct effect on renal epithelial transport was investigated in by: 4.

The purpose of this study is to investigate the effect of different doses of sodium nitrite infusion in 12 healthy subjects. The effects on renal handling of nitrite, nitrate, sodium and water, plasma concentrations of vasoactive hormones, peripheral (brachial) and central blood pressure will be evaluated.

of taurocholate was begun either or 4 hr after beginning the study. All of these perfusions were performed at 37'C. In a second set of experiments, the temperature of the perfusate was altered to study BSP transport at varying rates of bile flow. Sodium taurocholate was infused as de-scribed above, to dissociate direct effects of bile salt onFile Size: 1MB.

Taurocholate-induced haemolysis Treatment of rats with taurocholate dissolved in ADDITION OF HUMAN (H) OR RAT (R) SERUM ALBU- MIN PREVENTS THE TAUROCHOLATE-INDUCED IN- CREASE OF BILE PIGMENTS Infusion of (^mol/min/kg); Number of rats Biliary bilirubin output (amol/min/kg) taurocholate albumin 0 0 2 0 2 (H) 2 (H) 2 (R) 22 6 4 8 4 Cited by: 1.

The Effects of Sodium and Potassium on Blood Pressure, Vascular Function and Renal Function (KaNa) Change in renal function comparing (1) high sodium, low potassium intake and (2) low sodium, high potassium intake with low sodium, low potassium intake.

[ Time Frame: Screening. Baseline at week 1 (t=0). It is important to note that with the OVX procedure, not only is E lost, but also other ovarian hormones are removed which could have an impact on BP and renal function.

Sodium Reabsorption. With regards to sodium reabsorption, the data show that both E and T increased renal sodium by: Effects of beraprost sodium on renal function and inflammatory factors of rats with diabetic nephropathy J.

Guan1,2, L. Long 1, Y.-Q. Chen, Y. Yin 1, L. Li, C.-X. Zhang1, L. Deng 1 and L.-H. Tian 1Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China 2Nursing School of North Sichuan Medical College, Nanchong, Sichuan, China. The sodium taurocholate cotransporting polypeptide (NTCP) and the apical sodium dependent bile acid transporter (ASBT) ensure an effective circulation of (conjugated) bile acids.

Effects of beraprost sodium on renal function and inflammatory factors of rats with diabetic nephropathy The impact of the serum albumin level on. The excretory transport maximum (Tm) for taurocholate was determined in the perfused rat liver and compared to that obtained in the intact rat.

An in situ liver perfusion system employing a semisynthetic perfusion medium containing Krebs-Ringer-bicarbonate solution, bovine erythrocytes and bovine albumin was used. In contrast to the bromosulfophthalein (BSP)-Tm.

The quality and quantity of protein are essential factors that determine nutritional significance of a protein. The aim of this study was to compare the effects of several animal and plant proteins on the progression of renal failure in rats. Ninety male rats were allocated into nine groups and were fed with a basal diet containing different protein sources for 12 weeks.

The relationship between dietary sodium and the activity of representative renal enzymes of the three main metabolic pathways-oxydative breakdown, glycolysis and pentose-monophosphate-shunt-was studied in the rat kidney.

Enzyme assays were carried out on total tissue homogenates and isolated mitochondria of the cortex and medulla as well as on Author: M. Mályusz, G.

Mályusz, J. Girndt, B. Ochwadt. Effects of Chronic Alcohollntake and Secretory Stimulation on Sodium Taurocholate-lnduced Pancreatic Necrosis in the Rat JUHA M.

GRONROOS, M.D., HEIKKI J. AHO, M.D., AND TIMO J. NEVALAINEN, M.D. Department o{ Pathology, University o{ Turku, Turku, Finlond Submitted for publication May lO, METHODS.

Sodium-dependent uptake was only observed for PFOS by human ASBT (Fig. 7A) while none of the 3 PFASs were transported by rat ASBT (Fig. 7B). The proper function of human and rat ASBT was confirmed by measuring sodium-dependent transport of the model substrate [3 H]-taurocholate (Supplementary Data).Cited by: effects of added dietary sodium selenite in broiler, renal histopathological changes, ultrastructural changes, and renal function parameters.

sodium and calcium ions in the renal tubule [6]. How-ever, the precise mechanism for the dietary NaCl-induced urinary Ca2+ increase is not fully understood.

In addition, it is not clear if long-term salt loading has any effects on Ca2+-transporting molecule expressions in the kidney.

The bulk of Ca2+ in the pro-urine is reabsorbed in theCited by:   Serum electrolytes were similar between the normal- and high-salt fed rats. Food intake was similar between the groups (normal-salt vs high-salt groups, ± vs ± g/day, n.s., n=15 /group), although the high-salt group weighed slightly less than the normal-salt group at the end of the study (±5 vs ±4 g, P Cited by:   The sodium-glucose-cotransporter-2 (SGLT2) inhibitor dapagliflozin (DAPA) induces glucosuria and osmotic diuresis via inhibition of renal glucose reabsorption.

Since increased diuresis retards the progression of polycystic kidney disease (PKD), we investigated the effect of DAPA in the PCK rat model of PKD. DAPA (10 mg/kg/d) or vehicle was administered. Characterization and Purification of Bile Acid Transport Proteins.- Transport of Taurocholate in Isolated Cells from Ileum, Liver and Kidney.- Properties of the Taurocholate Uptake System in Basolateral Rat Liver Plasma Membrane Vesicles: Effects of Albumin and Substrate Specificity.- Hepatic Transport of Xenobiotics Abstract.

Systemic metabolic acidosis is known to cause a decrease in salt and water reabsorption by the kidney. We have used renal lithium clearance to investigate the effect of chronic, NH 4 Cl-induced metabolic acidosis on the renal handling of Na + in male Wistar-Hannover rats ( g).

Chronic acidosis (pH ± ) caused a sustained increase in. or intraduodenal infusions of taurocholate on rates of bile acid synthesis was studied in chow-fed rats. In these experiments groups of animals were given graded doses of sodium taurocho- late ranging from 0 to pmoles per kg per hr and of [“C] sodium taurocholate ranging from to pCi per kg per by: The main hormone that acts on the kidneys to regulate sodium ion concentration of the extracellullar fluid (ECF) is: A) epinephrine B) secretin C) renin D) aldosterone E) ADH.

within living cells. renal vein, segmental veins, interlobar veins, arcuate veins, cortical radiate veins. decrease in GFR and sodium excretion in rats receiving nabumetone. Conclusion: In contrast to the suggested renal-sparing effects of COX-2 inhibitors, we have ob-served renal function being affected with nabumetone during anesthetic stress.

KEY WORDS: Anesthetic stress, COX-2 inhibitors, kidney function Department of Physiology, School ofCited by: 1. The present studies were undertaken to determine the effect of aldosterone and cortisol on the sodium content of the kidney. Rats were injected intraperitoneally with 50 µg of d-aldosterone or µg of d,l-aldosterone, or with 2 mg of to four hours later the kidneys were removed and analyses of sodium and water in the papilla, medulla, and cortex were by: 6.

Information about the open-access article 'Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B1' in DOAJ.

DOAJ is an online directory that indexes and provides access to quality open access, peer-reviewed by: 9. Monosodium glutamate (MSG) was administrated to rats at doses of and mg/g body weight for 14 days.

Body weight and relative liver and kidney weight of rats were significantly increased. On regard to liver functions, the activities of alanine aminotransferase (ALT) and γ glutamyle transferase (GGT) significantly increased in the serum, on MSG administration, Cited by:   The jaundice is due to a combination of (i) bilirubin overproduction (because 10% of packed red cells haemolyse within 24 h and L of transfused packed cells will thus result in an extra production of mg bilirubin, doubling the normal daily production rate), (ii) decreased biliary secretion, because of inflammatory cytokines (which Cited by: bile flow.

Sodium taurocholate M (Maybridge, Corn- wall, U.K) in % sodium chloride and 3% bovine albumin was infused in the femoral vein cannulae at pmol/min/ g body wt and bile was collected in tared micro- centrifuge tubes at 5.

Kidney function changes after single-dose administration of borocaptate sodium (mercaptoundecahydro-closo- dodecaborate, B12H11SH, BSH) were studied in rats. Changes of glomerular filtration rate (GFR) measured as 14C-inulin clearance, renal plasma flow rate (3H-p-aminohippuric acid clearance) and urine flow rate (UFR) after.

Biochemical effects of cimetidine in rats Table 3: Effect of repeated administration of cimetidine ( -1 body weight) on some rat liver function parameters Days after Albumin (g.L-1) Total Bilirubin (umol.L-1) Administration Control Test Control Test 1 ±a ±a ±a ±a.

Albumin synthesis, alcohol and amino acid effects on (rabbit), Alcohol amino acids and, effects on albumin synthesis (rabbit), effect on ethanol concentrations and osmolality of pancreatic juice, bile, and portal and peripheral blood (dog), liver disease caused by, hypogonadism in, This has two effects: (1) a greater amount of sodium and chloride are left in the filtrate (and subsequently water remains in the filtrate too) and (2) the countercurrent exchange which drives concentrating the urine is disrupted—both effects result in more, less-concentrated excretions.

effects of amino acid combinations on renal hemodynamics and on renal excretory function and to determine whether these effects could be influenced by sodium dietary restriction. A low sodium diet was found to be efficacious in preventing the renal hemodynamic effects of amino acid infusions, and this preven.

Yamaguchi T, Wakabayashi Y, Tanaka M, Sano T, Ishikawa H, Nakajima H et al. Taurocholate induces directional excretion of bilirubin into bile in perfused rat liver. American Journal of Physiology - Gastrointestinal and Liver Physiology.

Jun 1;(6 ):GGCited by: Mechanism of the decreased renal blood flow in the potassium-depleted conscious rat. Although chronic potassium deficiency is a common clinical problem, the hemodynamic consequences of chronic sustained potassium depletion have not been clearly delineated.

In this study, the. The ocular barriers (cornea, blood–retinal barrier, and blood–aqueous humor barrier) make treating eye diseases with therapeutic drugs challenging. The tight capillary endothelium of the iris and the ciliary body epithelium form the blood–aqueous humor barrier.

The iris and ciliary body (iris-ciliary body) express a variety of drug transporters in the ATP-binding Cited by:. To differentiate between the “intact” and “sick” cell hypothesis explaining decreased clearance of endo‐ and xenobiotics, we measured uptake of taurocholate and ouabain in hepatocytes isolated from cirrhotic rat liver.

Cirrhosis was induced by chronic exposure of male Sprague‐Dawley rats to phenobarbital and carbon by: Free flashcards to help memorize facts about The Urinary System.

Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.The loss of the modulator role of the endothelium could be involved in the pathogenesis of diabetic vascular complications.

Transition metal compounds, such as tungsten and vanadium, have been proposed as possible agents in the treatment of diabetes by simulating the effects of insulin.

The mesenteric vascular bed intervenes in vascular resistance and is a source of .